解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Development of tolerance protocols requires assays or biomarkers that distinguish tolerant recipients from non-tolerant ones to be established. In addition, a thorough understanding of the plausible mechanisms associated with clinical transplant tolerance is necessary to take the field forward. Unlike the majority of ...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.009
更新日期:2018-05-01 00:00:00
abstract:PURPOSE:Graves' disease (GD) is a multigenic, organ specific autoimmune disorder with a strong genetic predisposition and IL-1β has been shown to be involved in its pathogenesis. The present study was aimed to determine the genetic associations between polymorphisms of IL-1β gene promoter region (-511 T>C) (rs16944), e...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.02.006
更新日期:2018-04-01 00:00:00
abstract::The role of interleukin-23 is crucial in the pathogenesis of psoriasis, and IL23A, IL12B and IL23R genetic variants have been associated with the disease in genome-wide association studies. In the current paper we have conducted a confirmation study of the abovementioned genetic factors in a case-control analysis of 5...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.02.003
更新日期:2018-04-01 00:00:00
abstract::DNA sequence-based typing at the HLA-A, -B, -C, -DPA1, -DPB1, -DQA1, -DQB1, -DRB1, and -DRB3/4/5 loci was performed on samples provided by 159 individuals from the Worcester region of the Western Cape province of South Africa. The purpose of the study was to characterize allele frequencies in the local population, to ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2018.01.004
更新日期:2018-03-01 00:00:00
abstract::The pathogenesis of many diseases is influenced by environmental factors which can affect human genome and be inherited from generation to generation. Adverse environmental stimuli are recognized through the epigenetic regulatory complex, leading to gene expression alteration, which in turn culminates in disease outco...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2018.01.003
更新日期:2018-03-01 00:00:00
abstract::DNA sequence-based typing at the HLA-A, -B, -C, -DPB1, -DQA1, -DQB1, and -DRB1 loci was performed on 714 healthy adult blood bank donors from Colombo, Sri Lanka, to characterize allele frequencies in support of studies on T cell immunity against pathogens, including Dengue virus. Deviations from Hardy Weinberg proport...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.12.007
更新日期:2018-02-01 00:00:00
abstract::Homozygous carriers of CCR5-Δ32, a gene variant of CC-type chemokine receptor 5 (CCR5), are highly resistant to infections with human immunodeficiency virus type 1 (HIV-1) and therefore preferred stem cell donors for HIV-infected patients. We analyzed CCR5 typing data of 1,333,035 potential hematopoietic stem cell don...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.10.001
更新日期:2017-11-01 00:00:00
abstract::Better outcome for hematopoietic stem cell transplantation (HSCT) requires optimal matching between donor and recipient at the HLA-A, -B, -C, and -DRB1 loci. This study estimates the likelihood of identifying HLA matched donors in Hong Kong. 7595 volunteer unrelated Chinese donors at the Hong Kong Bone Marrow Donor Re...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.08.007
更新日期:2017-10-01 00:00:00
abstract::The detrimental impact of preformed anti-HLA donor-specific antibodies (DSA) is well defined, contrarily to non-donor-specific antibodies (NDSA). We sought to evaluate their clinical impact in a cohort of 724 kidney graft recipients in whom anti-HLA antibodies were thoroughly screened and identified in pre-transplant ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.07.011
更新日期:2017-09-01 00:00:00
abstract::Natural killer (NK) cell activity is regulated by activating and inhibitory signals transduced by killer cell immunoglobulin-like receptors (KIR). Diversity in KIR gene repertoire among individuals may affect disease outcome. Sepsis development and severity may be influenced by genetic factors affecting the immune res...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.02.005
更新日期:2017-04-01 00:00:00
abstract::It is suggested that interleukin 10 (IL-10), as a modulator of immune response, is likely to influence the elimination of hepatitis C virus (HCV), the progression of chronic hepatitis C (CHC) and the response to interferon-based therapy in CHC patients. The aim of the study was to analyze the association of single nuc...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.10.015
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Type I hypersensitivity, also known as IgE-mediated allergy, is a complex, multifactorial condition whose onset and severity are influenced by both genetic and environmental factors. Mite allergens stimulate the production of humoral response (IgE), especially in children, which is closely involved in atopic...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.10.014
更新日期:2017-02-01 00:00:00
abstract::The acquired form of idiopathic thrombotic thrombocytopenic purpura (TTP) is an autoimmune disease, in which the underlying ADAMTS13-deficiency is caused by inhibitory autoantibodies against the protease. Human leukocyte antigens (HLA), responsible for antigen presentation, play an important role in the development of...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.11.005
更新日期:2017-02-01 00:00:00
abstract::Toll like receptors (TLRs) are a class of molecular pattern recognition receptors, elicits a strong inflammatory immune response against pathogens. Helicobacter pylori (H. pylori), a gram negative flagellate colonizes the human stomach, is responsible for the development of chronic gastritis and gastric carcinoma. The...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::The LABScreen single antigen bead assay (SAB) is a method widely used for the identification and monitoring of human leukocyte antigen (HLA) antibodies in patients pre-and post-transplant. While accurate testing of patient samples is key for optimal patient care, time can also be important, especially during deceased ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.05.001
更新日期:2017-01-01 00:00:00
abstract::"Those who do not know the past are destined to repeat it". The current system for the allocation of deceased donor kidneys that was implemented in December 2014 (termed the kidney allocation system (KAS)) was the culmination of a decade-long process. Thus, many people involved in transplantation today may not be awar...
journal_title:Human immunology
pub_type: 历史文章,杂志文章
doi:10.1016/j.humimm.2016.08.008
更新日期:2017-01-01 00:00:00
abstract::Septic patients develop immune dysfunctions, the intensities and durations of which are associated with deleterious outcomes. LILRB2 (leukocyte immunoglobulin-like receptors subfamily B, member 2), an inhibitory member of the LILR family of receptors, is known for its immunoregulatory properties. In a microarray study...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.03.010
更新日期:2017-01-01 00:00:00
abstract::Genetic variations in chemokine genes influence the chemoattractive properties of T cells which may be associated with outcome of infections. In present study, we have investigated the regulatory role played by In1.1T/C (rs2280789) polymorphism of CCL5 and -135G/A (rs56061981) polymorphism of CXCL10 gene on intracellu...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2017.03.008
更新日期:2017-01-01 00:00:00
abstract::The discovery of Pattern Recognition Receptors (PRRs) followed by that of their role in the early detection of pathogens and the ignition of the innate immune response has been a formidable progress for immunological research in the past 15years. This has massively fueled investigations aiming at developing better str...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.04.004
更新日期:2016-11-01 00:00:00
abstract::Antibody-mediated rejection (ABMR) is associated with poor transplant outcome. Pathogenic alloantibodies are usually directed against human leukocyte antigens (HLAs). Histological findings suggestive of ABMR usually demonstrate an anti-HLA donor-specific antibody (DSA)-mediated injury, while a small subset of patients...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.05.021
更新日期:2016-11-01 00:00:00
abstract:UNLABELLED:Early allograft dysfunction (EAD) after liver transplantation is mostly a reversible event caused by factors related to ischemia/reperfusion (I/R) injury. EAD represents a hepatic injury associated with pre- and early post-transplant inflammatory cytokine responses. Aim of the present study was to evaluate t...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.234
更新日期:2016-10-01 00:00:00
abstract::The goal of this study was to evaluate the influence of KIR-HLA genotypes on the outcome of patients undergoing treatment for haematological malignancies by non-T-depleted lymphocyte haematopoietic stem cell transplantation (HSCT) from HLA-matched sibling donors. The prospective study was conducted at the Center of He...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.003
更新日期:2016-10-01 00:00:00
abstract::The objective was to investigate whether phagocytes from healthy and septic newborns have a developmental deficiency in their capacity to recognize, phagocytize and generate hydrogen peroxide (H2O2) in response to Escherichia coli and Staphylococcus aureus. TLR expression and phagocytic ability of neutrophils and mono...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.07.230
更新日期:2016-10-01 00:00:00
abstract::Human leukocyte antigen-G (HLA-G) is an anti-inflammatory and immunosuppressive molecule that can modulate immune cell activation. The role of HLA-G in tuberculosis, an immune-mediated and chronic bacterial disease remains to be elucidated. We investigated the expression profile of soluble and membrane bound HLA-G in ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.01.004
更新日期:2016-09-01 00:00:00
abstract::DC-10 is a distinct subset of human tolerogenic dendritic cells (DCs) which express high levels of human leukocyte antigen-G (HLA-G). DC-10 could induce adaptive type 1 regulatory T cells through the IL-10 dependent ILT4/HLA-G signaling pathway. However, the significance of DC-10 in malignancies remains unclear. In th...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.01.003
更新日期:2016-09-01 00:00:00
abstract::Immune thrombocytopenia (ITP) is a heterogeneous autoimmune disease, characterized by dysregulation of cellular immunity. Th17 and associated IL-17 were involved in the pathogenesis of ITP. Runt-related transcription factor 1 (RUNX1), a member of the runt domain-containing family of transcription factors, is required ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.06.004
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:X-linked lymphoproliferative disease (XLP) is a rare life-threatening syndrome. Rapid recognition and definitive diagnosis are critical to improve the prognosis and survival of patients with XLP. Nowadays, little is known about patients with XLP in China. METHODS:We report the characterization of five Chine...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2016.06.005
更新日期:2016-08-01 00:00:00
abstract::Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity. Therapies targeting IL-6 and TNF-α have been utilized in treating chronic inflammatory diseases. Oligonol is a lychee fruit-derived low-molecula...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.011
更新日期:2016-06-01 00:00:00
abstract::Pronase treatment is used in the flow cytometry crossmatch (FCXM) to prevent nonspecific antibody binding on B cells. However, we have observed unexpected positive results with pronase-treated T cells in human immunodeficiency virus (HIV)-infected patients. In this study, 25 HIV-infected patients without HLA antibodie...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.014
更新日期:2016-06-01 00:00:00
abstract::The loss of melanocytes in vitiligo is mainly attributed to defective autoimmune mechanisms and lately autoinflammatory mediators have become more emphasized. Among these, a number of class II cytokines and their receptors have displayed altered expression patterns in vitiligo. Thus, we selected 30 SNPs from the regio...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.09.050
更新日期:2016-05-01 00:00:00
abstract::HLA-B∗15:02 is known as a biomarker for carbamazepine (CBZ) induced Steven-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS/TEN) in some Asian populations. Hence United States Federal Drug Administration (USFDA) recommends HLA-B∗15:02 screening for Asian and other populations with a high prevalence of HLA-B∗15:02,...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.04.001
更新日期:2016-05-01 00:00:00
abstract::Previous studies indicate the distribution of major histocompatibility complex class I chain-related genes A (MICA) and B (MICB) alleles and haplotypes varies widely between different ethnic populations and geographic areas. It is meaningful to investigate allelic frequencies and establish a genetic database. In this ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.03.005
更新日期:2016-05-01 00:00:00
abstract::While modern high-throughput sequence-based HLA genotyping methods generally provide highly accurate typing results, artefacts may nonetheless arise for numerous reasons, such as sample contamination, sequencing errors, read misalignments, or PCR amplification biases. To help detecting spurious typing results, we test...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2016.01.012
更新日期:2016-03-01 00:00:00
abstract::The maternal immune system must adapt to tolerate the invasion of the allogeneic feto-placental unit. It is generally accepted that improper adaptation causes pregnancy complications like preeclampsia. The Epstein-Barr virus-induced gene 3 (EBI3) protein is a subunit of immune-modulatory cytokines interleukin 27 (IL-2...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.10.004
更新日期:2016-01-01 00:00:00
abstract::CD8-positive γδ T lymphocytes (GDCD8(+)) are specifically increased in peripheral blood of Behçet's disease (BD) patients. GDCD8(+) have shown a T regulatory (Treg) function in autoimmune experimental models, human tumor infiltrates and intestinal intraepithelial lymphocytes from celiac patients. The aim of this study...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.10.001
更新日期:2016-01-01 00:00:00
abstract::This article hashas been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Human immunology
pub_type: 撤回出版物
doi:10.1016/j.humimm.2015.11.011
更新日期:2015-11-14 00:00:00
abstract::This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FcγRIIa, CD209, VDR, TNF-α, IL-4, IL-6 and IFN-γ genes with symptom ...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.09.026
更新日期:2015-10-01 00:00:00
abstract::Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing evidence that galectins are implicated in essential biological processes such as cellular communication, inflammation, differentiation and apoptosis. Galectin-3 is one of the best-known galectins, which is found in ver...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2015.09.036
更新日期:2015-10-01 00:00:00
abstract::Natural killer cells (NK) are pivotal cells of innate immunity. They are potent antileukemic cytotoxic effectors. A defect in their cytotoxicity has been described in some hematopoietic malignancies such as acute myeloid leukemia, multiple myeloma and myelodysplastic syndromes. This defect is at least partially linked...
journal_title:Human immunology
pub_type: 杂志文章
doi:10.1016/j.humimm.2015.09.010
更新日期:2015-09-01 00:00:00
abstract::Besides central tolerance peripheral tolerance is an important mechanism to avoid development of autoimmunity. Naturally occurring thymic-derived regulatory T cells (nTreg) mediate peripheral tolerance by suppressing autoreactive T cells clones having escaped thymic deletional control. This implies that nTreg have the...
journal_title:Human immunology
pub_type: 杂志文章,评审
doi:10.1016/j.humimm.2015.06.015
更新日期:2015-08-01 00:00:00